Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 32.00 | |
2 mg | In stock | $ 45.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 129.00 | |
25 mg | In stock | $ 283.00 | |
50 mg | In stock | $ 461.00 | |
100 mg | In stock | $ 677.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 72.00 |
Description | Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human). |
Targets&IC50 | mGlu4 (human):500 nM |
In vivo | Lu AF21934 treatment shows a dose-dependent anxiolytic-like effect in the stress-induced hyperthermia, four-plate, and marble-burying tests. The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test is inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and is not serotonin-dependent. Lu AF21934 does not produce antidepressant-like effects in the tail suspension test in mice; however, it decreases the basal locomotor activity of mice that are not habituated to activity cages. |
Kinase Assay | The receptor-expressing CHO cells are seeded into 24-well plates at a density of 4×104 cells/well and cultured for 1 day. The cells are then incubated with [5,6,8,9,11,12,14,15-3H]arachidonic acid (11 kBq/well) for 1 day and ished with DMEM supplemented with 20 mM HEPES and 0.2% BSA. The cells are then preincubated with the compounds (Sufugolix) at 37 °C for 60 min and the reaction is started by addition of LHRH (1 nM). After incubation at37 °C for 40 min, radioactivity in the medium is measured with a liquid scintillation counter[1]. |
Molecular Weight | 315.2 |
Formula | C14H16Cl2N2O2 |
CAS No. | 1445605-23-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (52.88 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Lu AF21934 1445605-23-1 Neuroscience GluR Inhibitor Metabotropic glutamate receptors inhibit Lu AF 21934 Lu AF-21934 mGluR inhibitor