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MALT1 inhibitor MI-2

Catalog No. T2350   CAS 1047953-91-2
Synonyms: MALT1 inhibitor, MI 2, MI 2 (MALT1 inhibitor)

MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
MALT1 inhibitor MI-2 Chemical Structure
MALT1 inhibitor MI-2, CAS 1047953-91-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 39.00
2 mg In stock $ 54.00
5 mg In stock $ 98.00
10 mg In stock $ 131.00
25 mg In stock $ 253.00
50 mg In stock $ 441.00
100 mg In stock $ 649.00
500 mg In stock $ 1,390.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.87%
Purity: 99.58%
Purity: 99.35%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
Targets&IC50 MALT1:5.84 μM
In vitro Daily intraperitoneal injection of 25 mg/kg MI-2 effectively inhibits the growth of TMD8 and HBL-1 ABC-DLBCL xenografts, while it has no effect on the growth of OCI-Ly1 tumors.
In vivo MI-2 demonstrates excellent cellular permeability and inhibits the function of MALT1 in the ABC-DLBCL cell lines. It selectively inhibits the growth of MALT1-dependent cell lines, with GI50 values of 0.2, 0.5, 0.4, and 0.4 μM in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, respectively. Conversely, ABC-DLBCL cell lines not dependent on MALT1, such as U2932 and HLY-1, along with two types of GCB-DLBCL cell lines, exhibit resistance to MI-2.
Kinase Assay High-Throughput Screening for MALT1 Proteolytic Activity Inhibitors: Ac-LRSR-AMC is used as substrate and reactions are measured with excitation/emission wavelengths of 360/465 nm. Two time points are measured for each reaction to eliminate false positives due to compound autofluorescence. The final percent inhibition is calculated with the formula {[fluorescencetest compound (T2-T1)-fluorescenceneg ctrl (T2-T1)]/[fluorescencepos ctrl (T2-T1)-fluorescenceneg ctrl (T2-T1)]} × 100, where Z-VRPR-FMK (300 nM) is used as positive control and buffer only as negative control. The positive hits are validated in concentration-response experiments within a dose range of 0.122–62.5 μM to determine IC50 of the compounds. Activity is validated using recombinant full-length wild-type MALT1.
Cell Research Cell proliferation is determined by ATP quantification using a luminescent method and trypan blue dye exclusion. Standard curves for each cell line are calculated by plotting the cell number (determined using trypan blue) against their luminescence values, and cell number is calculated accordingly. Cell viability in drug-treated cells is normalized to their respective controls (fractional viability), and results are given as 1-fractional viability. CompuSyn software is used to determine GI25 and GI50 values.(Only for Reference)
Synonyms MALT1 inhibitor, MI 2, MI 2 (MALT1 inhibitor)
Molecular Weight 455.72
Formula C19H17Cl3N4O3
CAS No. 1047953-91-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.6 mg/mL (100 mM)

Ethanol: 9.1 mg/mL (20 mM)

TargetMolReferences and Literature

1. Fontan L, et al. Cancer Cell. 2012, 22(6), 812-824.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Highly Selective Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Aging Compound Library Nonsteroidal Anti-Inflammatory Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Cysteine Covalent Library Immunology/Inflammation Compound Library

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Keywords

MALT1 inhibitor MI-2 1047953-91-2 Immunology/Inflammation MALT MALT1 inhibitor inhibit MI 2 MALT1 MI2 MI 2 (MALT1 inhibitor) MI-2 Inhibitor MALT-1 inhibitor MI-2 MALT1 inhibitor MI 2 mucosa associated lymphoid tissue lymphoma translocation gene 1 MALT1 inhibitor MI2 inhibitor

 

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