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MI-1061

MI-1061
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
Catalog No. T12031Cas No. 1410737-34-6
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MI-1061

Catalog No. T12031Cas No. 1410737-34-6
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$3,5986-8 weeks
50 mgInquiry6-8 weeks
100 mgInquiry6-8 weeks
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Product Introduction

Bioactivity
Description
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
Targets&IC50
MDM2:(ki)0.16 nM , MDM2:4.4 nM
In vitro
MI-1061 achieves IC50 of 100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively[1].
In vivo
MI-1061 was able to achieve tumor regression in oral SJSA-1 xenograft model mice[1].
Chemical Properties
Molecular Weight582.45
FormulaC30H26Cl2FN3O4
Cas No.1410737-34-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 300 mg/mL (515.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7169 mL8.5844 mL17.1689 mL85.8443 mL
5 mM0.3434 mL1.7169 mL3.4338 mL17.1689 mL
10 mM0.1717 mL0.8584 mL1.7169 mL8.5844 mL
20 mM0.0858 mL0.4292 mL0.8584 mL4.2922 mL
50 mM0.0343 mL0.1717 mL0.3434 mL1.7169 mL
100 mM0.0172 mL0.0858 mL0.1717 mL0.8584 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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