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MJN110

Catalog No. T5815   CAS 1438416-21-7
Synonyms: Cravatt Reagent

MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
MJN110 Chemical Structure
MJN110, CAS 1438416-21-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 79.00
25 mg In stock $ 178.00
50 mg In stock $ 288.00
100 mg In stock $ 519.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
Targets&IC50 MAGL:9.1 nM
In vivo The Selective Monoacylglycerol Lipase Inhibitor Cravatt Reagent Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
Animal Research For repeated administration experiments, mice were given vehicle, 0.0818 mg/kg MJN110, 0.469 or 10 mg/kg morphine, or a combination of 0.0818 mg/kg Cravatt Reagent?and 0.469 mg/kg morphine twice?daily for 5.5 days.?Then, mice underwent behavioral testing on day 6.?The combination of 0.0818 mg/kg MJN110 and 0.469 mg/kg morphine produced significant antinociceptive effects.
Synonyms Cravatt Reagent
Molecular Weight 462.33
Formula C22H21Cl2N3O4
CAS No. 1438416-21-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (59.48 mM)

TargetMolReferences and Literature

1. Wilkerson J L , Niphakis M J , Grim T W , et al. The selective monoacylglycerol lipase inhibitor MJN110 produces opioid sparing effects in a mouse neuropathic pain model[J]. Journal of Pharmacology and Experimental Therapeutics, 2016:jpet.115.229971.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Metabolism Disease Compound Library Metabolism Compound Library Bioactive Compounds Library Max Inhibitor Library NO PAINS Compound Library Lipid Metabolism Compound Library Anti-Obesity Compound Library Bioactive Compound Library Orally Active Compound Library

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MAGL-IN-1 ABX-1431 Y-320 PF-06795071 JZP-430 euphol JZP-361 AA38-3

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Keywords

MJN110 1438416-21-7 Metabolism Lipase MJN 110 MAGL Inhibitor Monoacylglycerol lipase MJN-110 inhibit Cravatt Reagent inhibitor

 

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