Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 79.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 288.00 | |
100 mg | In stock | $ 519.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. |
Targets&IC50 | MAGL:9.1 nM |
In vivo | The Selective Monoacylglycerol Lipase Inhibitor Cravatt Reagent Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. |
Animal Research | For repeated administration experiments, mice were given vehicle, 0.0818 mg/kg MJN110, 0.469 or 10 mg/kg morphine, or a combination of 0.0818 mg/kg Cravatt Reagent?and 0.469 mg/kg morphine twice?daily for 5.5 days.?Then, mice underwent behavioral testing on day 6.?The combination of 0.0818 mg/kg MJN110 and 0.469 mg/kg morphine produced significant antinociceptive effects. |
Synonyms | Cravatt Reagent |
Molecular Weight | 462.33 |
Formula | C22H21Cl2N3O4 |
CAS No. | 1438416-21-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (59.48 mM)
You can also refer to dose conversion for different animals. More
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MJN110 1438416-21-7 Metabolism Lipase MJN 110 MAGL Inhibitor Monoacylglycerol lipase MJN-110 inhibit Cravatt Reagent inhibitor