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Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD

Catalog No. T16486 CAS 1037589-69-7

Synonyms: PF-05231023

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist. It is also suitable for development as a potential treatment for T2DM.

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Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD Chemical Structure

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD, CAS 1037589-69-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 76.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 597.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 100%

Purity: 99.83%

Biological Description

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Storage & Solubility Information

Description	Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist. It is also suitable for development as a potential treatment for T2DM.
In vitro	PF-05231023 is a analog of long-acting fibroblast growth factor 21 [2].
In vivo	PF-05231023 suppresses oxidative-stress-induced inflammation in photoreceptors. PF-05231023 decreases the variability of retinal NRF2 levels and displays a trend (non-significant) towards increased NRF2 levels in Akita mice. PF-05231023 decreases retinal IL-1β mRNA expression in Akita mice. PF-05231023 enhances cone-specific arrestin4 expression in Akita mice. PF-05231023 restores photoreceptor morphology in Akita mice. Administration of native FGF21 and PF-05231023 (3?mg/kg or 10?mg/kg; subcutaneously twice a week for two weeks) improves glucose tolerance and liver insulin sensitivity in Zucker rats. PF-05231023 (10 mg/kg; intraperitoneally injected) reduces retinal inflammation in diabetic mice [3][4].

Synonyms	PF-05231023
Molecular Weight	528.55
Formula	C26H32N4O8
CAS No.	1037589-69-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (236.50 mM), Sonication is recommended.

References and Literature

1. Dong JQ, et al. Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study. Br J Clin Pharmacol. 2015 Nov;80(5):1051-63. 2. Giragossian C, et al. Mechanistic investigation of the preclinical pharmacokinetics and interspecies scaling of PF-05231023, a fibroblast growth factor 21-antibody protein conjugate. Drug Metab Dispos. 2015 Jun;43(6):803-11. 3. Bernardo B, et al. FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance. Sci Rep. 2015 Jul 8;5:11382. 4. Fu Z, et al. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 May;67(5):974-985. 5. Sonoda J, et al. FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases. Horm Mol Biol Clin Investig. 2017 May 19;30(2).

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Bioactive Compound Library Anti-Metabolism Disease Compound Library NO PAINS Compound Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max

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Keywords

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD 1037589-69-7 Angiogenesis PROTAC Tyrosine Kinase/Adaptors PROTAC Linker FGFR PF-05231023 Mal-amido-PEG-2-C2-amido-Ph-C2-CO-AZD PROTAC Linkers MalamidoPEG2C2amidoPhC2COAZD Inhibitor Mal amido PEG2 C2 amido Ph C2 CO AZD inhibit PF05231023 PF 05231023 inhibitor

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