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NIK SMI1

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

Catalog No. T16290Cas No. 1660114-31-7

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Purity:99.99%

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COA HNMR HPLC

NIK SMI1

Catalog No. T16290Cas No. 1660114-31-7

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

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Pack Size	Price	Availability
1 mg	$163	In Stock
5 mg	$413	In Stock
10 mg	$618	In Stock
25 mg	$985	In Stock
50 mg	$1,330	In Stock
100 mg	$1,790	In Stock
1 mL x 10 mM (in DMSO)	$455	In Stock

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Product Introduction

Bioactivity

Description	NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
In vitro	NIK SMI1 inhibits the expression of NIK SMI1 response element regulated firefly luciferase reporter gene in HEK293 cells (IC50: 34±6 nM). NIK SMI1 inhibits BAFF-induced B cell (mouse) survival in vitro with an IC50 of 373±64 nM. Consistent with expectations for a NIK inhibitor, NIK SMI1 is shown to inhibit nuclear translocation of p52 (RelB) (IC50=70 nM).
In vivo	The pharmacology of NIK SMI1 is examined in SD rat, CD-1 mouse, beagle, and cynomologous monkey with 20, 32, 18, and 7.8 mL/kg per min, respectively. The volume of distribution (Vd, L/kg) is 1.35, 1.58, 0.778, and 1.39, respectively. C57BL/6 mice are treated twice daily for 7 days with orally administered NIK SMI1 or with three injections of recombinant BAFF receptor fusion protein (Br3- mIgG2a) over the course of the 7-day experiment as a positive control .

Chemical Properties

Molecular Weight	365.38
Formula	C₂₀H₁₉N₃O₄
Cas No.	1660114-31-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (273.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7369 mL	13.6844 mL	27.3688 mL	136.8438 mL
5 mM	0.5474 mL	2.7369 mL	5.4738 mL	27.3688 mL
10 mM	0.2737 mL	1.3684 mL	2.7369 mL	13.6844 mL
20 mM	0.1368 mL	0.6842 mL	1.3684 mL	6.8422 mL
50 mM	0.0547 mL	0.2737 mL	0.5474 mL	2.7369 mL
100 mM	0.0274 mL	0.1368 mL	0.2737 mL	1.3684 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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