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Nigericin sodium salt

Catalog No. T3092 CAS 28643-80-3

Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-positive bacteria.

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Nigericin sodium salt Chemical Structure

Nigericin sodium salt, CAS 28643-80-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 209.00
50 mg	In stock	$ 312.00
100 mg	In stock	$ 468.00

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Purity: 99.52%

Purity: 99.05%

Purity: 98.2%

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Description	Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-positive bacteria.
In vitro	METHODS: Triple-negative breast cancer cells MDA-MB-231 and 4T1 were treated with Nigericin sodium (0.25-20 μg/mL) for 24 h. The cell viability of the cells was detected by the MTS. RESULTS: Nigericin sodium dose-dependently inhibited the cell viability of MDA-MB-231 and 4T1 cells with IC50 of 2.881 μM and 2.505 μM, respectively. [1] METHODS: Human lung cancer cells H460 were treated with Nigericin sodium (1 μM) for 24-48 h. Cell migration and invasion were detected by Transwell. RESULTS: Nigericin sodium significantly inhibited the migration and invasion of H460 cells. [2]
In vivo	METHODS: To detect anti-tumor activity in vivo, Nigericin sodium (2 mg/kg, subcutaneous injection every two days) and anti-PD-1 (250 μg/mouse, intraperitoneal injection once a week) were administered to BALB/c mice bearing triple-negative mammary adenocarcinoma tumor 4T1 for two weeks. RESULTS: PD-1 antibody alone did not show significant antitumor effects, while Nigericin sodium showed moderate antitumor effects.The combination of Nigericin sodium and anti-PD-1 almost completely inhibited tumor growth. [1] METHODS: To investigate the effects of aging on inflammatory vesicle function, Nigericin sodium (0.005 mg/g, 250 μL) was administered as a single intraperitoneal injection once daily for seven days to influenza virus-infected BALB/c mice. RESULTS: Treatment with Nigericin sodium during influenza infection increased IL-1β production, increased capase-1 activity, and reduced morbidity and mortality in aged mice. During influenza virus infection, NLRP3 inflammatory vesicle activity is impaired in aged mice, and Nigericin sodium treatment rescues NLRP3 in aged hosts.[3]

Molecular Weight	746.94
Formula	C40H67NaO11
CAS No.	28643-80-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3mg/mL(4.02 mM), Sonication is recommended.

Methanol: 122 mg/mL (163.33mM)

Ethanol: 50 mg/mL (66.94 mM), Sonication is recommended.

Ethanol: 47 mg/mL (62.92mM)

References and Literature

1. Wu L, et al. Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer. Cancers (Basel). 2023 Jun 16;15(12):3221. 2. Yakisich JS, et al. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol. 2017 Mar;39(3):1010428317694310. 3. Stout-Delgado HW, et al. Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin. J Immunol. 2012 Mar 15;188(6):2815-24. 4. Ju X, Zhu Y, Wang Y, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle[J]. PLoS pathogens. 2021, 17(3): e1009439.

Citations

1. Ju X, Zhu Y, Wang Y, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLoS pathogens. 2021, 17(3): e1009439.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Microbial Natural Product Library Pyroptosis Compound Library Natural Product Library Anti-Cancer Compound Library Ion Channel Inhibitor Library Antibiotics Library Natural Product Library for HTS NO PAINS Compound Library Anti-Breast Cancer Compound Library

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Keywords

Nigericin sodium salt 28643-80-3 Immunology/Inflammation Membrane transporter/Ion channel Microbiology/Virology NF-Κb Potassium Channel NOD-like Receptor (NLR) Antibacterial Antibiotic NOD Inhibitor Nigericin Bacterial inhibit Nigericin sodium KcsA inhibitor

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