Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function . |
In vitro | Verapamil's R isomer and its metabolite norverapamil have substantially less calcium channel blocking activity yet were similarly active as verapamil at inhibiting macrophage-induced drug tolerance.?Our finding that verapamil inhibits intracellular M. tuberculosis growth and tolerance suggests its potential for treatment shortening.?Norverapamil, R-verapamil, and potentially other derivatives present attractive alternatives that may have improved tolerability[1]. |
In vivo | Norverapamil is?a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively[2]. |
Synonyms | D591, (±)-Norverapamil |
Molecular Weight | 440.58 |
Formula | C26H36N2O4 |
CAS No. | 67018-85-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Norverapamil 67018-85-3 Membrane transporter/Ion channel Metabolism Calcium Channel D591 D 591 D-591 (±)-Norverapamil inhibitor inhibit