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Norverapamil hydrochloride
🥰Excellent
Catalog No. T16339Cas No. 67812-42-4
Alias D591 hydrochloride, (±)-Norverapamil hydrochloride
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
Norverapamil hydrochloride
🥰Excellent
Purity: 99.47%
Catalog No. T16339Alias D591 hydrochloride, (±)-Norverapamil hydrochlorideCas No. 67812-42-4
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 29 € | In Stock | |
| 5 mg | 107 € | In Stock | |
| 10 mg | 187 € | In Stock | |
| 25 mg | 315 € | In Stock | |
| 50 mg | 471 € | In Stock | |
| 100 mg | 658 € | In Stock | |
| 500 mg | 1.377 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 112 € | In Stock |
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Purity:99.47%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. |
| In vitro | Norverapamil inhibits macrophage-induced tolerance and attains serum levels comparable to verapamil. Both verapamil and its primary metabolite, Norverapamil, are identified as mechanism-based inhibitors and substrates of CYP3A, exhibiting non-linear pharmacokinetics clinically. Furthermore, ((±)-Norverapamil hydrochloride) proves as effective as verapamil in inhibiting tolerance and killing intracellular M. tuberculosis in monotherapy, matching its efficacy against isoniazid and rifampicin tolerance [1][3]. |
| In vivo | Norverapamil hydrochloride (9 mg/kg; p.o.) exhibits a terminal half-life of 9.4 hours, an AUC of 260 ng ml−1 h, and a Cmax of 41.6 ng/mL[4]. |
| Alias | D591 hydrochloride, (±)-Norverapamil hydrochloride |
| Molecular Weight | 477.04 |
| Formula | C26H37ClN2O4 |
| Cas No. | 67812-42-4 |
| Smiles | Cl.COc1ccc(CCNCCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (104.81 mM) DMSO: 31 mg/mL (64.98 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
pumpsP-gpPgpP-glycoproteinNorverapamil HydrochlorideNorverapamil hydrochlorideNorverapamilmycobacterialMultidrug resistance protein 1metaboliteMDR1M. tuberculosisInhibitorinhibiteffluxDrugMetaboliteDrug MetaboliteD-591 HydrochlorideD591 HydrochlorideD-591D591D 591 HydrochlorideD 591Cluster of differentiation 243CD243CalciumChannelCalcium ChannelCa2+ channelsCa channelsABCB1(±)-Norverapamil
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