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PACOCF3
Catalog No. T21907Cas No. 141022-99-3
Alias Palmityltrifluoromethylketone, 1,1,1-trifluoroheptadecan-2-one
PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2].
PACOCF3
Catalog No. T21907Alias Palmityltrifluoromethylketone, 1,1,1-trifluoroheptadecan-2-oneCas No. 141022-99-3
PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $55 | In Stock | |
| 25 mg | $98 | In Stock | |
| 50 mg | $168 | In Stock | |
| 100 mg | $272 | In Stock | |
| 200 mg | $396 | In Stock |
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Purity:99.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2]. |
| In vitro | PACOCF3 does not affect basal cytosolic free calcium concentrations ([Ca2+]i) at 20 μM, but a dosage between 50-250 μM triggers an increase in [Ca2+]i through the stimulation of extracellular Ca2+ entry, which can be partially inhibited by 50 μM La3+[2]. This PACOCF3-induced effect is negated when extracellular Ca2+ is removed. At a concentration of 10 μM, PACOCF3 amplifies the peak and the area under the curve of the [Ca2+]i surge elicited by 10 μM ATP and 1 μM bradykinin, by enhancing extracellular Ca2+ influx without altering internal Ca2+ release[2]. |
| Alias | Palmityltrifluoromethylketone, 1,1,1-trifluoroheptadecan-2-one |
| Molecular Weight | 308.42 |
| Formula | C17H31F3O |
| Cas No. | 141022-99-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (145.9 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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