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PF-05175157

Catalog No. T7163 CAS 1301214-47-0

PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively

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PF-05175157, CAS 1301214-47-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 61.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 193.00
50 mg	In stock	$ 385.00
100 mg	In stock	$ 593.00
1 mL * 10 mM (in DMSO)	In stock	$ 67.00

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Purity: 99.78%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively
Targets&IC50	ACC2 (rat):50.4 nM, ACC2 (human):33.0 nM , ACC1 (rat):23.5 nM , ACC1 (human):27.0 nM
In vivo	PF-05175157 induced a reduction of the viral load in serum and kidney in WNV-infected mice, unveiling its therapeutic potential for the treatment of chronic kidney disease associated with persistent WNV infection.
Animal Research	Pharmacokinetics was analyzed after a single oral dose of the compounds (in a 0.5% methyl cellulose suspension) administered to fasted male mice. A dose of 15 mg/kg for PF-05175157 or 100 mg/kg in the case of PF-05206574 and PF-06256254 was analyzed. Antiviral activity in vivo was determined using eight-week-old Swiss albino CD-1 female mice. Animals were treated with PF-05175157 (20 mg/kg) suspended in 1% carboxymethylcellulose by oral gavage twice a day from 1 d before infection with WNV (1 × 10^4 PFU/mouse intraperitoneally) and up to 7 days post-infection. Control mice were treated in parallel with drug vehicle (carboxymethylcellulose). For experiments evaluating the effect of genetic deletion of ACC2 gene on WNV infection, a breeding colony of C57BL/6 ACC2-/- mice was established from two heterozygous Acabtm1Dejs females . Age- and sex-matched eight-week-old ACC2-/- and control wild type (WT) mice were challenged with WNV (1 × 10^4 PFU/animal.). Animals were monitored daily and received water and food ad libitum.

Molecular Weight	405.49
Formula	C23H27N5O2
CAS No.	1301214-47-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (73.98 mM)

References and Literature

1. Jiménez de Oya, Nereida, Esler W P , Huard K , et al. Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models[J]. Emerging Microbes & Infections, 2019, 8(1):624-636.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Bioactive Compound Library Metabolism Compound Library ReFRAME Related Library Anti-Obesity Compound Library Clinical Compound Library Lipid Metabolism Compound Library Bioactive Compounds Library Max

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Keywords

PF-05175157 1301214-47-0 Metabolism Acetyl-CoA Carboxylase ACC, Acetyl Coenzyme A Carboxylase PF05175157 inhibit Inhibitor PF 05175157 inhibitor

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