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PSB-603
🥰Excellent
Catalog No. T23203Cas No. 1092351-10-4
Alias PSB 603
PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.
PSB-603
🥰Excellent
Purity: 97.13%
Catalog No. T23203Alias PSB 603Cas No. 1092351-10-4
PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $163 | In Stock | |
| 25 mg | $363 | In Stock | |
| 50 mg | $591 | In Stock | |
| 100 mg | $987 | In Stock | |
| 200 mg | $1,330 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $113 | In Stock |
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Purity:97.13%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects. |
| In vitro | In peripheral T cells, PSB-603 (100 nM) inhibits NECA-stimulated IL-6 release about 3-fold[2]. PSB-603 (10 μM) shows no affinity for the human and rat A1 and A2A and human A3 receptors[4]. |
| In vivo | PSB-603 (5 mg/kg; i.p.) significantly reduces inflammation in local and systemic mice models of inflammation. In the inflamed paw, PSB-603 significantly decreases the levels of the inflammatory cytokines including IL-6, TNF-α and of ROS. PSB-603 reduces inflammation of the peritoneum by decreasing the infiltration of leukocytes[3]. |
| Alias | PSB 603 |
| Molecular Weight | 529.01 |
| Formula | C24H25ClN6O4S |
| Cas No. | 1092351-10-4 |
| Smiles | CCCn1c(=O)[nH]c2[nH]c(nc2c1=O)-c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(Cl)cc1 |
| Relative Density. | 1.430 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 23.9 mg/mL (45.1 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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