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PSNCBAM-1

Catalog No. T28468 CAS 877202-74-9

Synonyms: PSNCBAM 1

PSNCBAM-1 is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.

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PSNCBAM-1, CAS 877202-74-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PSNCBAM-1 is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.
Targets&IC50	hCB1-R:0.1 μM (EC50)

Synonyms	PSNCBAM 1
Molecular Weight	392.88
Formula	C22H21ClN4O
CAS No.	877202-74-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/mL (139.99 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang X, et al. Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum. Mol Pharmacol. 2011 Apr;79(4):758-67. 2. Horswill JG, et al. PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br J Pharmacol. 2007 Nov;152(5):805-14. 3. Cawston EE, et al. Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol. 2013 Oct;170(4):893-907. 4. German N, et al. Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J Med Chem. 2014 Sep 25;57(18):7758-69.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PSNCBAM-1 877202-74-9 GPCR/G Protein Cannabinoid Receptor PSNCBAM1 PSNCBAM 1 inhibit Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.