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PY-60

Catalog No. T9566 CAS 2765218-56-0

PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermis through proliferation.

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PY-60, CAS 2765218-56-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 287.00
10 mg	In stock	$ 478.00
25 mg	In stock	$ 789.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
500 mg	In stock	$ 2,970.00
1 mL * 10 mM (in DMSO)	In stock	$ 318.00

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Purity: 99.32%

Purity: 98.86%

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Description	PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermis through proliferation.
Targets&IC50	ANXA2:1.4 µM
In vitro	PY-60 robustly increased the levels of YAP-controlled transcripts (that is, ANRKD1, CYR61 and CTGF) in 293A cells and other human cell lines (that is, MCF10A, HEK293T, H69 and HaCaT), but did not augment the levels of YAP itself (YAP1). PY-60 induced luciferase activity in 293A-TEAD-LUC cells in the presence or absence of serum when cells were plated at high cell density with EC50s of 1.5 and 1.6 µM, respectively. PY-60 also promoted the association of YAP and TEAD proteins in cells in a dose-dependent manner and induced the nuclear localization of YAP in response to increased cell density[1].
In vivo	PY-60 (10 uM) promoted a dramatic expansion of keratinocytes and K14-positive precursors. PY-60 resulted in an approximate doubling of epidermal thickness, a result derived from an increased number of keratinocytes per unit length of skin[1].

Molecular Weight	313.37
Formula	C16H15N3O2S
CAS No.	2765218-56-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (303.16 mM), Sonication is recommended.

References and Literature

1. Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021;17(7):767-775.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

PY-60 2765218-56-0 GPCR/G Protein Stem Cells YAP Annexin A PY60 PY 60 inhibitor inhibit

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