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Podocarpic acid

Catalog No. T12514 CAS 5947-49-9

Podocarpic acid is a natural product and a novel TRPA1 activator.

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Podocarpic acid, CAS 5947-49-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 59.00
25 mg	In stock	$ 94.00
50 mg	In stock	$ 136.00
100 mg	In stock	$ 198.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Podocarpic acid is a natural product and a novel TRPA1 activator.
In vitro	Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA)[1].
In vivo	Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels[1].

Molecular Weight	274.35
Formula	C17H22O3
CAS No.	5947-49-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (364.50 mM)

References and Literature

1. Baraka HN. Microbial transformation of podocarpic acid and evaluation of transformation products for antioxidant activity. Planta Med. 2010 May;76(8):815-7. 2. Singh S, et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2824-8.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Selected Plant-Sourced Compound Library Natural Product Library Bioactive Compound Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Ion Channel Inhibitor Library Neuronal Signaling Compound Library Bioactive Compounds Library Max RO5 Drug-like Natural Product Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Podocarpic acid 5947-49-9 Membrane transporter/Ion channel Others TRP/TRPV Channel inhibit Transient receptor potential channels TRP Channel Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.