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Polyinosinic-polycytidylic acid

Catalog No. T23171 CAS 24939-03-5

Synonyms: Poly(I:C)

Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.

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Polyinosinic-polycytidylic acid Chemical Structure

Polyinosinic-polycytidylic acid, CAS 24939-03-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 45.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 148.00
50 mg	In stock	$ 283.00
100 mg	In stock	$ 439.00
500 mg	In stock	$ 987.00

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Description	Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.
In vitro	METHODS: Cervical cancer cells HeLa, SiHa, C33A and lung cancer cells A549 were treated with polyinosinic-polycytidylic acid (0.1-1 μg/mL) for 24 h, and cell death was detected using PI Staining. RESULTS: Polyinosinic-polycytidylic acid effectively induced tumor cell death in a dose-dependent pattern. [1] METHODS: Rat astrocytes were pretreated with polyinosinic-polycytidylic acid (10-20 μg/mL) for 12 h, and then exposed to oxygen-glucose deprivation (OGD) for 12 h. The morphology of the cells was examined by microscopy. RESULTS: OGD induced significant cellular damage, and the cells appeared to be healthier in the group pretreated with polyinosinic-polycytidylic acid.Polyinosinic-polycytidylic acid exerted a certain degree of protective effect against OGD-induced damage in cultured astrocytes. [2]
In vivo	METHODS: To investigate the neuroprotective effects in an acute ischemia model, Polyinosinic-polycytidylic acid (0.3 mg/kg) was administered as a single intramuscular injection to Kun-Ming strain mice, and a model of arterial occlusion (MCAO) was constructed 2 h later. RESULTS: Administration of polyinosinic-polycytidylic acid significantly attenuated neurological deficits in the ischemic striatum and cortex, reduced infarct volume, and suppressed the elevation of TNFα and IL-6 levels. [2] METHODS: To test the antitumor activity in vivo, Polyinosinic-polycytidylic acid (1-100 μg/mouse) was intraperitoneally injected into a mouse model of metastatic tumors C57BL/6J induced by cutaneous melanoma B16-F10. RESULTS: Lung tumor growth stopped after a single dose of Polyinosinic-polycytidylic acid. Polyinosinic-polycytidylic acid has potential antitumor activity in an established mouse model of lung metastasis. [3]

Synonyms	Poly(I:C)
Molecular Weight	N/A
Formula	(C10H13N4O8P)x.(C9H14N3O8P)x
CAS No.	24939-03-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: ≥21.5mg/mL

DMSO: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Meng X, et al. poly(I:C) synergizes with proteasome inhibitors to induce apoptosis in cervical cancer cells. Transl Oncol. 2022 Apr;18:101362. 2. Pan LN, et al. Toll-like receptor 3 agonist Poly I:C protects against simulated cerebral ischemia in vitro and in vivo. Acta Pharmacol Sin. 2012 Oct;33(10):1246-53. 3. Forte G, et al. Polyinosinic-polycytidylic acid limits tumor outgrowth in a mouse model of metastatic lung cancer. J Immunol. 2012 Jun 1;188(11):5357-64.

Citations

1. Li Y, Ma X, Yue Y, et al. Rapid surface display of mRNA antigens by bacteria‐derived outer membrane vesicles for a personalized tumor vaccine. Advanced Materials. 2022: 2109984. 2. Li Y, Ma X, Yue Y, et al. Rapid Surface Display of mRNA Antigens by Bacteria-Derived Outer Membrane Vesicles for a Personalized Tumor Vaccine. Advanced Materials. 2022: 2109984 3. Ma N, Chen Z, Liu G, et al.Normalizing the Immune Macroenvironment via Debulking Surgery to Strengthen Tumor Nanovaccine Efficacy and Eliminate Metastasis.ACS Nano.2022 4. Yang Q, Liu T, Zhou Z, et al.A nanoformulation for immunosuppression reversal and broad-spectrum self-amplifying antitumor ferroptosis-immunotherapy.Biomaterials.2022: 121936.

Related compound libraries

This product is contained In the following compound libraries：

Pyroptosis Compound Library Nucleotide Compound Library NO PAINS Compound Library

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Keywords

Polyinosinic-polycytidylic acid 24939-03-5 Immunology/Inflammation TLR Toll-like Receptor (TLR) Poly(I:C) Polyinosinic polycytidylic acid Inhibitor inhibit Polyinosinicpolycytidylic acid inhibitor

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