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RFRP3(human) acetate(311309-27-0 free base)

Catalog No. TP1936L1 CAS TP1936L1

RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM.

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RFRP3(human) acetate(311309-27-0 free base), CAS TP1936L1

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Purity: 98%

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Description

In vitro

RFRP-3(human) acetate efficiently inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM. Scatchard-plot analysis shows that 125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kd value and the Bmax values are 0.19 nM and 1.3 pM, respectively. RFRP-3(human) acetate specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1].

Molecular Weight	1029.19
Formula	C47H76N14O12
CAS No.	TP1936L1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. IJ Clarke, IP Sari, Y Qi,etc. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion.[J]. Endocrinology, 2008(11):5811.

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Keywords

RFRP3(human) acetate(311309-27-0 free base) TP1936L1 G蛋白偶联受体神经科学 Neuropeptide Y Receptor RFRP-3(human) acetate(311309-27-0 free base) RFRP3(human) acetate(311309 27 0 free base) RFRP3(human) acetate(311309270 free base) Inhibitor inhibitor inhibit

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