Powder: -20°C for 3 years
In solvent: -80°C for 2 years
RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM.
Description | RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM. |
In vitro | RFRP-3(human) acetate efficiently inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM. Scatchard-plot analysis shows that 125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kd value and the Bmax values are 0.19 nM and 1.3 pM, respectively. RFRP-3(human) acetate specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1]. |
Molecular Weight | 1029.19 |
Formula | C47H76N14O12 |
CAS No. | TP1936L1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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RFRP3(human) acetate(311309-27-0 free base) TP1936L1 G蛋白偶联受体 神经科学 Neuropeptide Y Receptor RFRP-3(human) acetate(311309-27-0 free base) RFRP3(human) acetate(311309 27 0 free base) RFRP3(human) acetate(311309270 free base) Inhibitor inhibitor inhibit