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RP-54745

Catalog No. T5641 CAS 135330-08-4

RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.

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RP-54745, CAS 135330-08-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
2 mg	In stock	$ 132.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 337.00
25 mg	In stock	$ 572.00
50 mg	In stock	$ 818.00
100 mg	In stock	$ 1,130.00
1 mL * 10 mM (in DMSO)	In stock	$ 323.00

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Purity: 98%

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Description	RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.
In vivo	RP-54745 might diminishe?LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1],RP-54745 might influence cells and cytokines implicated in the regulation of the immune system, the disfunctioning of which can lead to inflammatory disorders or autoimmune pathologies[2]
Animal Research	1.5*10^6 peritoneal murine macrophages, after a 2-h period of adherence, were cultured in RPMI 1640 with 5% FCS for 20 h at 37 ℃ in 5% CO2.?In vitro, test compounds were added 15 min before the stimulant, 100ng/ml LPS, and the cells were incubated for 2-24 h. In vivo, thioglycollate-stimulated female OFt mice were orally treated with 5 or 25 mg/kg/day RP 54745 for 4 days.?Harvested macrophages were then stimulated ex vivo for 2 h with LPS at concentrations ranging from 0.1-10 ng/ml.?In some assays, 4 h before macrophage harvesting, mice were treated intraperitoneally with LPS: 0.5 ug per mouse.?At the end of the in vitro incubation period, supernatants were removed from cultures, and cells were lysed by three freeze/thaw cycles.?Both extracellular and cell-associated IL-1 activities were assayed.

Molecular Weight	297.82
Formula	C13H12ClNOS2
CAS No.	135330-08-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL (209.86 mM)

References and Literature

1. Folliard F , Bousseau A , Terlain B . RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production[J]. Agents and Actions, 1992, 36(1-2):119-126. 2. Folliard F , Bousseau A , Terlain B . RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models[J]. Agents and Actions, 1992, 36(1-2):127-135.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library ReFRAME Related Library Nonsteroidal Anti-Inflammatory Compound Library Bioactive Compounds Library Max

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Keywords

RP-54745 135330-08-4 Immunology/Inflammation Interleukin RP 54745 inhibit RP54745 Inhibitor Interleukin Related inhibitor

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