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RPR104632
Catalog No. T16797Cas No. 154106-92-0
RPR104632 is a novel and potent antagonist located at the NMDA glycine site with neuroprotective activity.
RPR104632
Catalog No. T16797Cas No. 154106-92-0
RPR104632 is a novel and potent antagonist located at the NMDA glycine site with neuroprotective activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $700 | 6-8 weeks | |
| 5 mg | $1,800 | 6-8 weeks |
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Purity:99.06%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RPR104632 is a novel and potent antagonist located at the NMDA glycine site with neuroprotective activity. |
| Targets&IC50 | Neuro:4 μM (EC50), Neuroprotection:4 μM (EC50), [3H]-TCP:55 nM, Cerebral cortex:4.9 nM (Ki,rat), Cerebellar slices:890 nM (rat) |
| In vitro | RPR104632 antagonizes the binding of [3H]5,7-dichlorokynurenic acid to the rat cerebral cortex with a Ki of 4.9 nM. In the presence of N-methyl-D-aspartate (NMDA), RPR104632 inhibits [3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding with an IC50 of 55 nM. In a non-competitive manner, RPR104632 inhibits the NMDA-evoked increase in guanosine 3',5'-cyclic monophosphate (cGMP) levels of neonatal rat cerebellar slices (IC50 = 890 nM) and markedly reduces NMDA-induced neurotoxicity in rat hippocampal slices and cortical primary cell cultures. While MK-801 (1 μM) completely protects the CA1 and CA3 pyramidal neurones against NMDA-induced toxicity, these effects are not blocked by glycine. RPR104632 consistently produces a significant neuroprotective effect against all NMDA-induced toxicity and has no effect when added alone at concentrations up to 10 μM. The neuroprotective potency of RPR104632 is characterized by an EC50 of 4 μM[1]. |
| Molecular Weight | 466.13 |
| Formula | C15H11BrCl2N2O4S |
| Cas No. | 154106-92-0 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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