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S107

Catalog No. T3438Cas No. 927871-76-9

S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

S107

S107

Purity: 99.63%
Catalog No. T3438Cas No. 927871-76-9
S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.
Pack SizePriceAvailabilityQuantity
2 mg$32In Stock
5 mg$58In Stock
10 mg$88In Stock
25 mg$160In Stock
50 mg$268In Stock
100 mg$382In Stock
200 mg$543In Stock
1 mL x 10 mM (in DMSO)$64In Stock
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Purity:99.63%
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Product Introduction

Bioactivity
Description
S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.
In vitro
S107, a small compound, enhances calstabin2 binding to RyR2 at low nanomolar concentrations and does not interact with over 400 receptors, enzymes, and ion channels at up to 10 μM. It shows no effect on cardiac ion channels, including voltage-gated Na+, K+, and Ca2+ channels, or on normal Ca2+ signaling in cells[1]. S107 is a potential candidate for treating catecholaminergic polymorphic ventricular tachycardia (CPVT), exerting antiarrhythmic effects on CPVT-hiPSC-CMs. Pre-incubation with 10 μM S107 significantly reduces the incidence of CPVT-hiPSC-CMs presenting DADs to 25% by stabilizing the closed state of ryanodine receptor 2[2]. S107 may improve skeletal muscle function by stabilizing the RyR1-FKBP12 complex, increasing FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12 but not in the presence of oxidized glutathione. It reverses the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites[3].
In vivo
S107 effectively inhibits seizures and arrhythmias in mutant mice without blocking the channel or changing normal calcium (Ca2+) signaling; it specifically prevents leakage in the channel[1].
Chemical Properties
Molecular Weight209.31
FormulaC11H15NOS
Cas No.927871-76-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (262.77 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.7776 mL23.8880 mL47.7760 mL238.8801 mL
5 mM0.9555 mL4.7776 mL9.5552 mL47.7760 mL
10 mM0.4778 mL2.3888 mL4.7776 mL23.8880 mL
20 mM0.2389 mL1.1944 mL2.3888 mL11.9440 mL
50 mM0.0956 mL0.4778 mL0.9555 mL4.7776 mL
100 mM0.0478 mL0.2389 mL0.4778 mL2.3888 mL

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