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SAR7334

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Purity:99.62%

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COA HPLC HNMR

SAR7334

Catalog No. T12849Cas No. 1333210-07-3

SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).

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Pack Size	Price	Availability
1 mg	$65	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$425	In Stock
50 mg	$597	In Stock
100 mg	$747	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock

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Product Introduction

Bioactivity

Description	SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
In vitro	SAR7334 is an inhibitor of TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226 nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents (IC50 of 7.9 nM). SAR7334 (100 nM) substantially reduces TRPC6 currents[3].
In vivo	In isolated perfused lungs from mice, SAR7334 (10mg/kg, p.o.) inhibits TRPC6-dependent acute HPV . SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].
Alias	TRCP6-IN-1

Chemical Properties

Molecular Weight	367.87
Formula	C21H22ClN3O
Cas No.	1333210-07-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 350 mg/mL (951.42 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7184 mL	13.5918 mL	27.1835 mL	135.9176 mL
5 mM	0.5437 mL	2.7184 mL	5.4367 mL	27.1835 mL
10 mM	0.2718 mL	1.3592 mL	2.7184 mL	13.5918 mL
20 mM	0.1359 mL	0.6796 mL	1.3592 mL	6.7959 mL
50 mM	0.0544 mL	0.2718 mL	0.5437 mL	2.7184 mL
100 mM	0.0272 mL	0.1359 mL	0.2718 mL	1.3592 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc