Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 93.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 323.00 | |
50 mg | In stock | $ 593.00 | |
100 mg | In stock | $ 848.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor. |
In vitro | SB204990 treatment leads to a reduction in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels [1]. |
In vivo | When administered orally to rats, SB 204990 achieves systemic circulation and induces a dose-related reduction in plasma cholesterol (up to 46%) and triglyceride levels (up to 80%) upon inclusion in their diet at 0.05-0.25% (w/w) for one week. Similarly, a daily dose of 25 mg/kg of SB 204990 in dogs decreases plasma cholesterol (up to 23%) and triglyceride levels (up to 38%), with a preferential reduction in low-density lipoprotein compared to high-density lipoprotein cholesterol levels [2]. |
Molecular Weight | 389.27 |
Formula | C18H22Cl2O5 |
CAS No. | 154566-12-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (256.89 mM)
H2O: 10 mg/mL (25.69 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SB 204990 154566-12-8 Metabolism ATP Citrate Lyase Inhibitor inhibit ACLY SB204990 SB-204990 inhibitor