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SMS2-IN-2

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Purity:98%

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COA HNMR

SMS2-IN-2

Catalog No. T7263Cas No. 2241838-28-6

SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.

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Pack Size	Price	Availability
1 mg	$116	In Stock
2 mg	$169	In Stock
5 mg	$288	In Stock
10 mg	$449	In Stock
25 mg	$739	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
1 mL x 10 mM (in DMSO)	$295	In Stock

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Product Introduction

Bioactivity

Description	SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
Alias	SMS2 inhibitors

Chemical Properties

Molecular Weight	369.78
Formula	C19H13ClFN3O2
Cas No.	2241838-28-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (676.08 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7043 mL	13.5216 mL	27.0431 mL	135.2155 mL
5 mM	0.5409 mL	2.7043 mL	5.4086 mL	27.0431 mL
10 mM	0.2704 mL	1.3522 mL	2.7043 mL	13.5216 mL
20 mM	0.1352 mL	0.6761 mL	1.3522 mL	6.7608 mL
50 mM	0.0541 mL	0.2704 mL	0.5409 mL	2.7043 mL
100 mM	0.0270 mL	0.1352 mL	0.2704 mL	1.3522 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc