Shopping Cart
- Remove All
Your shopping cart is currently empty
SN 2
🥰Excellent
Catalog No. T12941Cas No. 823218-99-1
SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.
SN 2
🥰Excellent
Purity: 99.20%
Catalog No. T12941Cas No. 823218-99-1
SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $44 | In Stock | |
| 10 mg | $69 | In Stock | |
| 25 mg | $152 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $437 | In Stock | |
| 200 mg | $613 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "SN 2"
Camphor
Cited
Formosa, Bornan-2-one, 2-Camphanone, 2-Bornanone, (±)-Camphor
T295276-22-2
Camphor (2-Camphanone) is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
- $29
Size
QTY
CitedPregnenolone
Arthenolone, 3β-Hydroxy-5-pregnen-20-one
T0851145-13-1
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
- $45
Size
QTY
trans-Cinnamaldehyde
Phenylacrolein, Cinnamic aldehyde, Cinnamaldehyde, Cinnamal
T3S155314371-10-9
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells in vitro, down-regulation of the expression and function of BCR-ABL may be one of its most important anti-leukemia mechanisms. 3. Cinnamic aldehyde and cinnamic acid are cardioprotective in a rat model of ischemic myocardial injury, the mechanism is related to anti-oxidative and anti-inflammatory properties.
- $33
Size
QTY
Caffeic Acid Cited
T2807331-39-5
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities.
- $33
Size
QTY
Cited(-)-Menthol
Menthomenthol, Menthacamphor, L-Menthol, Levomenthol
T14072216-51-5
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.
- $31
Size
QTY
Probenecid Cited
Benemid
T045757-66-9
Probenecid (Benemid) is a benzoic acid derivative with antihyperuricemic property.
- $37
Size
QTY
CitedCapsaicin
Cited
Zostrix, Qutenza, 8-Methyl-N-vanillyl-trans-6-nonenamide, (E)-Capsaicin
T1062404-86-4
Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities.
- $50
Size
QTY
CitedMethyl salicylate
Wintergreen oil, Natural wintergreen oil, Methyl 2-hydroxybenzoate, Gaultheria oil, Betula oil, 2-Carbomethoxyphenol
T0399119-36-8
Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments.
- $33
Size
QTY
(+)-Camphor
D-Camphor, D-(+)-Camphor, (1R)-(+)-Camphor
T0882464-49-3
(+)-Camphor (D-Camphor) is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
- $41
Size
QTY
Oleoyl Serotonin
T221241002100-44-8In house
Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.
- $59
Size
QTY
1,4-Cineole
Isocineole
TQ0001470-67-7
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
- $41
Size
QTY
Fingolimod hydrochloride Cited
FTY720 HCl, Fingolimod (FTY720) HCl
T2539162359-56-0
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
- $35
Size
QTY
CitedSelect Batch
Purity:99.20%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SN 2 is a novel and potent TRPML3 ion channel activator(EC50 of 1.8±0.13 μM). |
| Targets&IC50 | TRPML1: >29.9 μM , TRPML3:1.13 μM(EC50) |
| In vitro | When activated with 10 μM SN-2, at -80 mV, the conductance of the TRPML3 channel is approximately 10 pS. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone.SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at 80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). |
| Molecular Weight | 255.35 |
| Formula | C17H21NO |
| Cas No. | 823218-99-1 |
| Smiles | Cc1cc(C)c(C2=NOC3C4CCC(C4)C23)c(C)c1 |
| Relative Density. | 1.27 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (65.27 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy SN 2 | purchase SN 2 | SN 2 cost | order SN 2 | SN 2 chemical structure | SN 2 in vitro | SN 2 formula | SN 2 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.