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SN 2

Catalog No. T12941 CAS 823218-99-1

SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.

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SN 2, CAS 823218-99-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 73.00
10 mg	In stock	$ 119.00
25 mg	In stock	$ 253.00
50 mg	In stock	$ 495.00
100 mg	In stock	$ 729.00
500 mg	In stock	$ 1,490.00
1 mL * 10 mM (in DMSO)	In stock	$ 80.00

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Purity: 99.20%

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Description	SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.
Targets&IC50	TRPML1: >29.9 μM , TRPML3:1.13 μM(EC50)
In vitro	When activated with 10 μM SN-2, at -80 mV, the conductance of the TRPML3 channel is approximately 10 pS. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone.SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at 80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K).

Molecular Weight	255.35
Formula	C17H21NO
CAS No.	823218-99-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (391.62 mM), Sonication is recommended.

References and Literature

1. Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48. 2. Zhiqiang Xia, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Aug 26;104922.

Related compound libraries

This product is contained In the following compound libraries：

Ion Channel Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Viral Compound Library Neuronal Signaling Compound Library

Related Products

Related compounds with same targets

AP 18 Methyl syringate TRPA1 Antagonist 1 NGD-8243 GSK1016790A LASSBio-1135 Pyr3 AMG 333

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Keywords

SN 2 823218-99-1 Membrane transporter/Ion channel TRP/TRPV Channel SN-2 inhibit Transient receptor potential channels SN2 TRP Channel Inhibitor inhibitor

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