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T6167923

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Purity:99.23%

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COA LCMS HNMR

T6167923

Catalog No. T13063Cas No. 2437475-16-4

T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6167923 impedes NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity and boasts improved anti-inflammatory effects, with IC50s values of 2.7 μM for IFN-γ, 2.9 μM for IL-1β, and 2.66 μM each for IL-6 and TNF-α, demonstrating its efficacy across multiple inflammatory mediators [1].

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Pack Size	Price	Availability
1 mg	$183	In Stock
2 mg	$272	In Stock
5 mg	$463	In Stock
10 mg	$695	In Stock
25 mg	$1,230	In Stock
50 mg	$1,670	In Stock
100 mg	$2,250	In Stock
1 mL x 10 mM (in DMSO)	$467	In Stock

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	458.39
Formula	C17H20BrN3O3S2
Cas No.	2437475-16-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (545.39 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1815 mL	10.9077 mL	21.8155 mL	109.0774 mL
5 mM	0.4363 mL	2.1815 mL	4.3631 mL	21.8155 mL
10 mM	0.2182 mL	1.0908 mL	2.1815 mL	10.9077 mL
20 mM	0.1091 mL	0.5454 mL	1.0908 mL	5.4539 mL
50 mM	0.0436 mL	0.2182 mL	0.4363 mL	2.1815 mL
100 mM	0.0218 mL	0.1091 mL	0.2182 mL	1.0908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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