Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6167923 impedes NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity and boasts improved anti-inflammatory effects, with IC50s values of 2.7 μM for IFN-γ, 2.9 μM for IL-1β, and 2.66 μM each for IL-6 and TNF-α, demonstrating its efficacy across multiple inflammatory mediators [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 183.00 | |
5 mg | In stock | $ 463.00 | |
10 mg | In stock | $ 788.00 | |
25 mg | In stock | $ 1,230.00 | |
50 mg | In stock | $ 1,670.00 | |
100 mg | In stock | $ 2,250.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 468.00 |
Description | T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6167923 impedes NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity and boasts improved anti-inflammatory effects, with IC50s values of 2.7 μM for IFN-γ, 2.9 μM for IL-1β, and 2.66 μM each for IL-6 and TNF-α, demonstrating its efficacy across multiple inflammatory mediators [1]. |
Molecular Weight | 458.39 |
Formula | C17H20BrN3O3S2 |
CAS No. | 2437475-16-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (545.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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T6167923 2437475-16-4 Immunology/Inflammation MyD88 T-6167923 T 6167923 inhibitor inhibit