Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB). EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1β on chemically induced long-term potentiation (LTP)-triggered protein synthesis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 123.00 | |
5 mg | In stock | $ 293.00 | |
10 mg | In stock | $ 393.00 | |
25 mg | In stock | $ 658.00 | |
50 mg | In stock | $ 937.00 | |
100 mg | In stock | $ 1,270.00 | |
500 mg | In stock | $ 2,550.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 460.00 |
Description | EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB). EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1β on chemically induced long-term potentiation (LTP)-triggered protein synthesis. |
In vivo | Notably, a novel TIR domain peptidomimetic (EM163) blocked both the activation of p38 and the suppression of cLTP-dependent protein synthesis by IL-1β. Our data support a model where IL-1β suppresses LTP directly in neurons by inhibiting mTOR-dependent translation.[1] |
Molecular Weight | 849.88 |
Formula | C44H60IN5O4 |
CAS No. | 1206480-93-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 76.5 mg/mL (90.0 mM)
You can also refer to dose conversion for different animals. More
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EM 163 1206480-93-4 Immunology/Inflammation MAPK MyD88 p38 MAPK IL Receptor EM-163 EM163 inhibitor inhibit