Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 148.00 | |
2 mg | Inquiry | $ 267.00 | |
5 mg | Inquiry | $ 592.00 |
Description | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. |
In vitro | TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells. |
Molecular Weight | 613.62 |
Formula | C28H38F3N5O7 |
CAS No. | T4122 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
You can also refer to dose conversion for different animals. More
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TAPI-1 trifluoroacetate (163847-77-6(free base)) T4122 Proteases/Proteasome MMP TAPI1 trifluoroacetate (171235715(free base)) TAPI 1 trifluoroacetate (171235 71 5(free base)) inhibitor inhibit