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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $196 | In Stock | |
5 mg | $438 | In Stock | |
10 mg | $623 | In Stock |
Description | TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors. |
In vitro | TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. [1] TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). [2] TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. [3] TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells. [4] |
Cell Research | Five thousand cells are seeded into each well of 96-well plates and their viability is assessed by CellTiter-Glo Luminescent Cell Viability assay. Upon serum deprivation for 24 h, the cells are treated with Ang II for 60 h with and without pretreatment with each inhibitor and antagonist. The assay substrates are then added to each well on the plate and the samples are evaluated using a luminometer. (Only for Reference) |
Alias | TAPI 1, TAPI, TAPI-1 |
Molecular Weight | 499.612 |
Formula | C26H37N5O5 |
Cas No. | 163847-77-6 |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 92 mg/mL (184.1 mM) H2O: 55 mg/mL (110.1 mM) DMSO: 92 mg/mL (184.1 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
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