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TAPI-1 trifluoroacetate (163847-77-6(free base))
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Purity:98.06%
TAPI-1 trifluoroacetate (163847-77-6(free base))
Catalog No. T4122
TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $148 | Backorder | |
| 2 mg | $267 | Backorder | |
| 5 mg | $592 | Backorder |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. |
| In vitro | TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells. |
| Molecular Weight | 613.62 |
| Formula | C28H38F3N5O7 |
| Cas No. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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