Shopping Cart
- Remove All
Your shopping cart is currently empty
TAPI-1 trifluoroacetate (163847-77-6(free base))
😃Good
Catalog No. T4122
TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
TAPI-1 trifluoroacetate (163847-77-6(free base))
😃Good
Purity: 98.06%
Catalog No. T4122
TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $148 | Backorder | |
| 2 mg | $267 | Backorder | |
| 5 mg | $592 | Backorder |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "TAPI-1 trifluoroacetate (163847-77-6(free base))"
Doxycycline
Cited
Vibramycin, Doxytetracycline, Doxycyclinum, Doxiciclina
T1687564-25-0
Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity.
- $45
Size
QTY
CitedGlucosamine Cited
D-Glucosamine, Chitosamine
T04293416-24-8
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
- $50
Size
QTY
CitedEdaravone Cited
MCI-186
T040789-25-8
Edaravone (MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
- $43
Size
QTY
CitedDoxycycline (hyclate)
WC2031, Doxycycline hydrochloride hemiethanolate hemihydrate, Doxycycline hyclate
T1687L24390-14-5
Doxycycline hyclate (WC2031) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline hyclate has antibacterial activity and antitumor activity.
- $41
Size
QTY
Astragaloside IV Cited
AST-IV, AS-IV
T297384687-43-4
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
- $32
Size
QTY
CitedStigmasterol Cited
Stigmasterin, beta-Stigmasterol
T296783-48-7
Stigmasterol (Stigmasterin) is a phytosterol with major functions in the maintenance of cell membrane structure and physiology. Stigmasterol lowers cholesterol levels and has anti-tumor, anti-inflammatory, and immunomodulatory effects.
- $55
Size
QTY
CitedBovine Type II Collagen
Collagen Type II,Bovine
T800259007-34-5
Bovine Type II Collagen (Collagen Type II,Bovine) is a homologous superhelical structure consisting of three identical α1(II) chains, and is a major component of animal cartilage. Type II collagen has a variety of biological activities, including maintaining cartilage tissue integrity, inducing immune tolerance, and stimulating chondrocyte growth and redifferentiation.
- $36
Size
QTY
Glucosamine sulfate
D-Glucosaminesulfate, D-Glucosamine sulphate
T279229031-19-4
Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.
- $41
Size
QTY
Triolein
Glycerol trioleate, Glycerine Trioleate
T3S0640122-32-7
Glyceryl Trioleate has been investigated for the treatment of Adrenoleukodystrophy.
- $39
Size
QTY
Ethyl gallate Cited
Phyllemblin, Nipagallin A, gallic acid ethyl ester
T3729831-61-8
Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB and inhibits hydrogen peroxide signaling, may represent an alternative class of vasopressors for use in septic shock. Also, Ethyl gallate suppresses proliferation and invasion in human breast cancer cells by modulating the PI3K/Akt pathway, which may contribute to inhibiting their downstream targets such as NF-κB p-65, Bcl-2/Bax, and mRNA levels of MMP-2 and MMP-9 in breast cancer cells, could be used as potential antioxidants with safe therapeutic application in cancer chemotherapy.
- $42
Size
QTY
CitedArctigenin Cited
(-)-Arctigenin
T29577770-78-7
(-)-Arctigenin ((-)-Arctigenin) is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Arctigenin is a lignan found in certain plants of the Asteraceae, including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin.
- $50
Size
QTY
CitedFenofibric acid
Trilipix, NSC 281318, FNF acid
T140242017-89-0
Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
- $33
Size
QTY
Select Batch
Purity:98.06%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. |
| In vitro | TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells. |
| Molecular Weight | 613.62 |
| Formula | C28H38F3N5O7 |
| Smiles | OC(=O)C(F)(F)F.CC(C)CC(CC(=O)NO)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](C)C(=O)NCCN |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy TAPI-1 trifluoroacetate (163847-77-6(free base)) | purchase TAPI-1 trifluoroacetate (163847-77-6(free base)) | TAPI-1 trifluoroacetate (163847-77-6(free base)) cost | order TAPI-1 trifluoroacetate (163847-77-6(free base)) | TAPI-1 trifluoroacetate (163847-77-6(free base)) chemical structure | TAPI-1 trifluoroacetate (163847-77-6(free base)) in vitro | TAPI-1 trifluoroacetate (163847-77-6(free base)) formula | TAPI-1 trifluoroacetate (163847-77-6(free base)) molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.