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TC-A 2317 hydrochloride
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Catalog No. T23426Cas No. 1245907-03-2
TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A (Ki of 1.2 nM) and Aurora kinase B (Ki of 101 nM), exhibiting antitumor activity.
TC-A 2317 hydrochloride
😃Good
Catalog No. T23426Cas No. 1245907-03-2
TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A (Ki of 1.2 nM) and Aurora kinase B (Ki of 101 nM), exhibiting antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $3,180 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A (Ki of 1.2 nM) and Aurora kinase B (Ki of 101 nM), exhibiting antitumor activity. |
| Targets&IC50 | Aurora A:1.2 nM (Ki), Aurora B:101 nM (Ki) |
| In vivo | In rats, TC-A 2317 hydrochloride (30 mg/kg;p.o.) shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h). In the antitumor mice model, TC-A 2317 hydrochloride is effective without a decrease of body weight[1]. |
| Molecular Weight | 392.93 |
| Formula | C19H29ClN6O |
| Cas No. | 1245907-03-2 |
| Smiles | CC(CCCC(C)(O)C)NC(N=C(NC1=NNC(C)=C1)C=C2C)=C2C#N.Cl |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: <39 mg/mL Ethanol: <19.50 mg/mL |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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