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Trabodenoson
🥰Excellent
Catalog No. T34914Cas No. 871108-05-3
Alias PJ-875, PJ875, PJ 875, INO-8875, INNO-8875, INNO8875, INNO 8875
Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma.
Trabodenoson
🥰Excellent
Purity: 99.94%
Catalog No. T34914Alias PJ-875, PJ875, PJ 875, INO-8875, INNO-8875, INNO8875, INNO 8875Cas No. 871108-05-3
Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $133 | In Stock | |
| 2 mg | $196 | In Stock | |
| 5 mg | $328 | In Stock | |
| 10 mg | $492 | In Stock | |
| 25 mg | $787 | In Stock | |
| 50 mg | $1,070 | In Stock | |
| 100 mg | $1,430 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $363 | In Stock |
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Purity:99.94%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma. |
| In vitro | Treatment with Trabodenoson significantly increases MMP-2 activity and MMP-14 abundance, while decreasing expression of fibronectin and collagen IV[2]. |
| In vivo | Trabodenoson (6.0%) demonstrates an average IOP drop of 2.45 ± 0.38 mm Hg in young mice over 7 days (downregulation)[2]. In induced eyes, topical trabodenoson significantly upregulates nestin expression in the ONH compared with vehicle-treated non-induced eyes[1]. Trabodenoson-treated eyes show significantly reduced optic nerve (ON) edema compared with vehicle-treated eyes. Additionally, RGC counts are higher in Trabodenoson-treated eyes compared to vehicle, accounting for 74% versus 47% of the contralateral eye[1]. |
| Alias | PJ-875, PJ875, PJ 875, INO-8875, INNO-8875, INNO8875, INNO 8875 |
| Molecular Weight | 380.36 |
| Formula | C15H20N6O6 |
| Cas No. | 871108-05-3 |
| Smiles | O[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@H]([C@@H]1O)n1cnc2c(NC3CCCC3)ncnc12 |
| Relative Density. | 1.87 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (262.91 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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