Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
2 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 94.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 337.00 | |
50 mg | In stock | $ 533.00 | |
100 mg | In stock | $ 769.00 |
Description | UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays. |
Targets&IC50 | G9a:63 pM (ki), G9a:6-9 nM, GLP:15-23 nM |
In vitro | UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1]. UNC0321 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM[2]. |
Molecular Weight | 515.69 |
Formula | C27H45N7O3 |
CAS No. | 1238673-32-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.33 mg/ml (6.46 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UNC0321 1238673-32-9 Chromatin/Epigenetic Histone Methyltransferase H3K9me2 SAR PKMT H3K9 UNC-0321 quinazoline inhibit K373 UNC 0321 p53 G9a GLP Inhibitor inhibitor