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Z-FY-CHO
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Catalog No. T41236Cas No. 167498-29-5
Alias Z-Phe-Tyr-CHO
Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP.
Z-FY-CHO
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Catalog No. T41236Alias Z-Phe-Tyr-CHOCas No. 167498-29-5
Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | 35 days | |
| 5 mg | $268 | 35 days | |
| 10 mg | $493 | 35 days | |
| 25 mg | $1,140 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP. |
| In vitro | Cell death induced by 6-OHDA was reduced using Z-FY-CHO (10 μM, 1 h pretreatment).Z-FY-CHO inhibited the increase in CTSL protein expression in 6-OHDA-treated SH-SY5Y cells.Z-FY-CHO treatment resulted in an increase in LC3-II expression and a decrease in P62 expression was decreased, indicating enhanced autophagic activity. In addition, Z-FY-CHO blocked the activation of caspase-3 and PARP. [1] The radiosensitization of U251 cells was significantly improved by using the specific cathepsin L inhibitor Z-FY-CHO (10 μM) or transfection with cathepsin L shRNA. Both inhibition and knockdown of cathepsin L in U251 cells enhanced radiation-induced DNA damage and G2/M phase cell cycle arrest. Also, inhibition or knockdown of cathepsin L increased radiation-induced apoptosis as evidenced by elevated Bax levels and decreased Bcl-2 levels. [2] |
| In vivo | In an ovariectomized mouse model of osteoporosis, intraperitoneal injection of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks was able to dose-dependently reduce bone weight loss.Z-FY-CHO acts as an inhibitor of bone resorption by inhibiting collagen degradation. [3] |
| Alias | Z-Phe-Tyr-CHO |
| Molecular Weight | 446.5 |
| Formula | C26H26N2O5 |
| Cas No. | 167498-29-5 |
| Smiles | [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=C(O)C=C2)C=O)=O)NC(OCC3=CC=CC=C3)=O |
| Relative Density. | 1.249 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (179.17 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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