z-fy-cho

Z-FY-CHO (Z-Phe-Tyr-CHO) is a specific and potent cathepsin L (CTSL) inhibitor [1][2].

Z-Pro-Pro-CHO acts as a prolyl oligopeptidase inhibitor with half-maximal inhibitory concentrations (IC50) of 0.16 μM for human prolyl oligopeptidase and 0.01 μM for Schistosoma mansoni prolyl oligopeptidase [1].

Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM and also serves as an inhibitor of NF-κB nuclear translocation, as documented in references [1] [2].

Z-LLNle-CHO is a cell permeable inhibitor of gamma-secretase. Z-LLNle-CHO induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.

Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a selective and potent proteasome inhibitor, with inhibition constants (Ki) of 1.5 µM for branched-chain amino acid-preferred, 2.3 µM for small neutral amino acid-preferred, and 40.5 µM for chymotrypsin-like activities, and an inhibitory concentration (IC50) of 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity [1].