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ACH-806
Catalog No. T14095Cas No. 870142-71-5
Alias GS9132
ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.
ACH-806
Catalog No. T14095Alias GS9132Cas No. 870142-71-5
ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM. |
| Targets&IC50 | HCV:（EC50）14 nM |
| In vitro | ACH-806, an NS4A antagonist, effectively hinders the replication of the Hepatitis C Virus (HCV) with an EC50 value of 14 nM. Treatment with ACH-806 notably decreases the immunoprecipitation levels of labeled NS3 and NS4A by anti-NS3 antibody. It significantly reduces NS3 and NS4A levels and facilitates p14 formation in original replicon cells, albeit not affecting ACH-806-resistant cells[1]. Moreover, ACH-806 administration leads to notable reductions in NS3 and NS4A within transfected cells, mirroring effects observed in replicon cells treated with the compound, where both NS3 and NS4A levels decrease significantly. Following ACH-806 treatment, NS3 amounts are diminished approximately 6-fold (100/16), and NS4A-bound NS3 is reduced roughly 29-fold (261/9). |
| Alias | GS9132 |
| Molecular Weight | 411.44 |
| Formula | C19H20F3N3O2S |
| Cas No. | 870142-71-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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