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ACT-678689
🥰Excellent
Catalog No. T14119Cas No. 1783256-96-1
Alias Compound Example 1.53.4
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
ACT-678689
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Purity: 99.46%
Catalog No. T14119Alias Compound Example 1.53.4Cas No. 1783256-96-1
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $129 | In Stock | |
| 5 mg | $272 | In Stock | |
| 10 mg | $413 | In Stock | |
| 25 mg | $689 | In Stock | |
| 50 mg | $953 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $342 | In Stock |
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Purity:99.46%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1]. |
| Targets&IC50 | TPH:8 nM |
| In vitro | TPH consists of two isoforms, TPH1 and TPH2. TPH1 is primarily found in peripheral tissues, especially the enterochromaffin cells (EC) in the gut, and is vital for the synthesis of 5HT, which is stored in the circulating blood platelets[1]. Conversely, TPH2 is predominantly expressed in neuronal cell types within the central nervous system (CNS). |
| Alias | Compound Example 1.53.4 |
| Molecular Weight | 565.04 |
| Formula | C23H22ClFN6O4S2 |
| Cas No. | 1783256-96-1 |
| Smiles | C(COC1=C(Cl)N=C(NS(C)(=O)=O)C=C1)(=O)N2[C@H](C=3N4C(=NC3CC2)SC(C)=N4)C5=C(F)C=C(C)C=C5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL (212.37 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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