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AE-3763

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Catalog No. T10254Cas No. 291778-77-3

AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.

AE-3763

AE-3763

😃Good
Catalog No. T10254Cas No. 291778-77-3
AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.
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Product Introduction

Bioactivity
Description
AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.
Targets&IC50
Neutrophil elastase (human):29 nM
In vitro
AE-3763 has potent inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.
In vivo
The infusion of AE-3763 significantly inhibits edema and leukocyte infiltration into the lung and improves the survival rate by 24 hours in a mouse model of fatal shock with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when administered intravenously by infusion (ED50: 0.42 mg/kg/h) or bolus injection (1.2 mg/kg). Preliminary studies indicate no overt toxic effects of AE-3763 (300 mg/kg, i.v.) in mice.
Animal Research
D-Galactosamine shock is induced in C3H/HeN mice (6-7 w, 22-25 g). AE-3763 (10 or 100 mg/kg) is administrated intraperitoneally six times at 2 h interval. Control animals receive the vehicle (PBS) instead of AE-3763. The animal survival rate is observed up to 24 h after shock induction.
Chemical Properties
Molecular Weight549.54
FormulaC23H34F3N5O7
Cas No.291778-77-3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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