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AE-3763
Catalog No. T10254Cas No. 291778-77-3
AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.
AE-3763
Catalog No. T10254Cas No. 291778-77-3
AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,190 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM. |
| Targets&IC50 | Neutrophil elastase (human):29 nM |
| In vitro | AE-3763 has potent inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water. |
| In vivo | The infusion of AE-3763 significantly inhibits edema and leukocyte infiltration into the lung and improves the survival rate by 24 hours in a mouse model of fatal shock with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when administered intravenously by infusion (ED50: 0.42 mg/kg/h) or bolus injection (1.2 mg/kg). Preliminary studies indicate no overt toxic effects of AE-3763 (300 mg/kg, i.v.) in mice. |
| Animal Research | D-Galactosamine shock is induced in C3H/HeN mice (6-7 w, 22-25 g). AE-3763 (10 or 100 mg/kg) is administrated intraperitoneally six times at 2 h interval. Control animals receive the vehicle (PBS) instead of AE-3763. The animal survival rate is observed up to 24 h after shock induction. |
| Molecular Weight | 549.54 |
| Formula | C23H34F3N5O7 |
| Cas No. | 291778-77-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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