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Aficamten

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Purity:99.39%

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COA HPLC HNMR

Aficamten

Catalog No. T9258Cas No. 2364554-48-1

Aficamten is a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$77	In Stock
5 mg	$189	In Stock
10 mg	$297	In Stock
25 mg	$597	In Stock
50 mg	$852	In Stock
100 mg	$1,170	In Stock
500 mg	$2,350	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Product Introduction

Bioactivity

Description

Aficamten is a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.

Chemical Properties

Molecular Weight	337.38
Formula	C18H19N5O2
Cas No.	2364554-48-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (192.66 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9640 mL	14.8201 mL	29.6402 mL	148.2008 mL
5 mM	0.5928 mL	2.9640 mL	5.9280 mL	29.6402 mL
10 mM	0.2964 mL	1.4820 mL	2.9640 mL	14.8201 mL
20 mM	0.1482 mL	0.7410 mL	1.4820 mL	7.4100 mL
50 mM	0.0593 mL	0.2964 mL	0.5928 mL	2.9640 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4820 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc