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Agnuside

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Purity:99.81%

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COA HPLC HNMR

Agnuside

Catalog No. T3868Cas No. 11027-63-7

Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.

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Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$98	In Stock
10 mg	$148	In Stock
25 mg	$249	In Stock
50 mg	$369	In Stock
100 mg	$548	In Stock
1 mL x 10 mM (in DMSO)	$110	In Stock

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Product Introduction

Bioactivity

Description	Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.
In vitro	Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant [2].
In vivo	Agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia.3 It also suppresses production of the pro-inflammatory mediators' prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.4
Alias	chasteberry oil

Chemical Properties

Molecular Weight	466.44
Formula	C22H26O11
Cas No.	11027-63-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (107.19 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1439 mL	10.7195 mL	21.4390 mL	107.1949 mL
5 mM	0.4288 mL	2.1439 mL	4.2878 mL	21.4390 mL
10 mM	0.2144 mL	1.0719 mL	2.1439 mL	10.7195 mL
20 mM	0.1072 mL	0.5360 mL	1.0719 mL	5.3597 mL
50 mM	0.0429 mL	0.2144 mL	0.4288 mL	2.1439 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0719 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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