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Ampkinone

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Catalog No. T10312Cas No. 1233082-79-5

Ampkinone is an indirect AMPK activator.

Ampkinone

Ampkinone

😃Good
Catalog No. T10312Cas No. 1233082-79-5
Ampkinone is an indirect AMPK activator.
Pack SizePriceAvailabilityQuantity
5 mg$55035 days
10 mg$96035 days
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Product Introduction

Bioactivity
Description
Ampkinone is an indirect AMPK activator.
In vitro
Ampkinone promotes AMPK phosphorylation through an LKB1-dependent mechanism, enhancing glucose absorption in muscle cells. This activation occurs indirectly in several cell lines, leading to increased glucose uptake.
In vivo
Ampkinone treatment in DIO mice results in significant reductions in total body weight and overall fat mass, effectively improving metabolic abnormalities in this model.
Chemical Properties
Molecular Weight505.52
FormulaC31H23NO6
Cas No.1233082-79-5
Relative Density.1.353 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (98.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9782 mL9.8908 mL19.7816 mL98.9081 mL
5 mM0.3956 mL1.9782 mL3.9563 mL19.7816 mL
10 mM0.1978 mL0.9891 mL1.9782 mL9.8908 mL
20 mM0.0989 mL0.4945 mL0.9891 mL4.9454 mL
50 mM0.0396 mL0.1978 mL0.3956 mL1.9782 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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