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Phenformin hydrochloride
🥰Excellent
Catalog No. T1453Cas No. 834-28-6
Alias Phenformin HCl, Phenethylbiguanide hydrochloride
Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
Phenformin hydrochloride
🥰Excellent
Purity: 99.23%
Catalog No. T1453Alias Phenformin HCl, Phenethylbiguanide hydrochlorideCas No. 834-28-6
Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 g | $42 | In Stock | |
| 5 g | $66 | In Stock |
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Purity:99.23%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. |
| In vitro | In H441 cells, phenformin increased AMPK activity while decreasing basal ion transport. In isolated hearts, Phenformin increased AMPK activity and phosphorylation. Phenformin significantly induced apoptosis in LKB1-deficient NSCLC cell lines. |
| In vivo | In H441 cells, phenformin increased AMPK activity while decreasing basal ion transport. In isolated hearts, Phenformin increased AMPK activity and phosphorylation. Phenformin significantly induced apoptosis in LKB1-deficient NSCLC cell lines. |
| Kinase Assay | Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of?32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method. |
| Alias | Phenformin HCl, Phenethylbiguanide hydrochloride |
| Molecular Weight | 241.72 |
| Formula | C10H16ClN5 |
| Cas No. | 834-28-6 |
| Smiles | Cl.NC(=N)NC(=N)NCCc1ccccc1 |
| Relative Density. | 1.24 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (248.22 mM)  H2O: 44 mg/mL (182 mM) Ethanol: 10 mg/mL (41.4 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/H2O/DMSO
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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