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Anti-inflammatory agent 47
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Catalog No. T79480Cas No. 2925288-12-4
Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1].
Anti-inflammatory agent 47
😃Good
Catalog No. T79480Cas No. 2925288-12-4
Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1]. |
| In vitro | Compound Flo8, at concentrations of 5 μM and 10 μM administered for 18 hours, exhibited minimal inhibitory effects on the viability of BV2 microglial cells [1]. Furthermore, at a concentration of 5 μM over 18 hours, it significantly inhibited the production of reactive oxygen species (ROS) in BV2 cells [1]. The same concentrations of Compound Flo8 over 18 hours also reduced the expression of inflammatory cytokines in BV2 cells, consequently decreasing apoptosis levels in SH-SY5Y cells [1]. Additionally, Compound Flo8 inhibited M1 polarization and promoted M2 polarization in microglia following LPS induction at 5 μM and 10 μM for 18 hours [1]. It also suppressed the phosphorylation of ERK, p38, and JNK in BV2 cells induced by LPS [1]. |
| In vivo | Compound Flo8 (15/35 mg/kg, intraperitoneal injection, daily/biweekly) alleviates neuroinflammation and inhibits neuronal apoptosis in the brains of MPTP-induced C57BL/6J mice [1]. |
| Molecular Weight | 394.42 |
| Formula | C25H18N2O3 |
| Cas No. | 2925288-12-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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