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Anticancer agent 105
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Catalog No. T78957Cas No. 2450987-57-0
Anticancer agent 105, a thienopyrimidine scaffold-based compound, exhibits selective toxicity towards melanoma and induces apoptosis. Additionally, it significantly inhibits metastatic nodules, including in a pulmonary metastatic melanoma mouse model [1], while demonstrating good safety and anticancer properties.
Anticancer agent 105
😃Good
Catalog No. T78957Cas No. 2450987-57-0
Anticancer agent 105, a thienopyrimidine scaffold-based compound, exhibits selective toxicity towards melanoma and induces apoptosis. Additionally, it significantly inhibits metastatic nodules, including in a pulmonary metastatic melanoma mouse model [1], while demonstrating good safety and anticancer properties.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
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Chemical Properties
| Description | Anticancer agent 105, a thienopyrimidine scaffold-based compound, exhibits selective toxicity towards melanoma and induces apoptosis. Additionally, it significantly inhibits metastatic nodules, including in a pulmonary metastatic melanoma mouse model [1], while demonstrating good safety and anticancer properties. |
| In vitro | Anticancer agent 105 (compound 9cb) shows selectivity against cancer cells with an IC50 of 2.41 μM for B16-F10 melanoma cells, while exceeding 100 μM for normal fibroblasts (MEF NF2) [1]. At 0.5-10 μM over 24 hours, it exhibits cytotoxic effects on cancer cells, and at 5-20 μM over 48 hours, it induces apoptosis and necrosis in B16-F10 cells [1]. |
| In vivo | Anticancer agent 105 [compound 9cb] at a dosage of 9-9.5 mg/kg administered intraperitoneally every three days for a duration of 22 days, inhibited metastatic nodules in C57BL/6 mice bearing B16-F10 melanoma [1]. |
| Molecular Weight | 533.64 |
| Formula | C25H24KN3O6S |
| Cas No. | 2450987-57-0 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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