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Antitumor agent-86
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Catalog No. T75078Cas No. 2907704-65-6
Antitumor agent-86 (compound 5a) demonstrates efficacy against MCF-7 breast cancer cells with an inhibitory concentration (IC 50) of 2.62 µM, promoting apoptosis and cell cycle arrest by disrupting the RAS/PI3K/Akt/JNK signaling pathways [1].
Antitumor agent-86
Antitumor agent-86
😃Good
Catalog No. T75078Cas No. 2907704-65-6
Antitumor agent-86 (compound 5a) demonstrates efficacy against MCF-7 breast cancer cells with an inhibitory concentration (IC 50) of 2.62 µM, promoting apoptosis and cell cycle arrest by disrupting the RAS/PI3K/Akt/JNK signaling pathways [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antitumor agent-86 (compound 5a) demonstrates efficacy against MCF-7 breast cancer cells with an inhibitory concentration (IC 50) of 2.62 µM, promoting apoptosis and cell cycle arrest by disrupting the RAS/PI3K/Akt/JNK signaling pathways [1]. |
| In vitro | Antitumor agent-86, administered at concentrations ranging from 0-200 μM for 48 hours, dose-dependently suppresses proliferation in MCF-7, MDA-MB-231, Caco-2, and PANC-1 cancer cell lines, with respective IC50 values of 2.617, 6.778, 14.8, and 23.58 μM [1]. At a concentration of 2.62 μM over 48 hours, it induces apoptosis, cell cycle arrest, reduces levels of p-RAS protein in MCF-7 cells, decreases mRNA transcription levels of PI3K and Akt, and lowers the expression of p-JNK protein [1]. Furthermore, Antitumor agent-86 upregulates the expression of the p21 gene at the same concentration and duration [1]. |
| Molecular Weight | 513.65 |
| Formula | C29H31N5O2S |
| Cas No. | 2907704-65-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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