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Antitumor agent-96
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Catalog No. T78970
"Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing the endonuclease functions of MRE11, thereby inducing apoptosis in CM cells [1]."
Antitumor agent-96
Antitumor agent-96
😃Good
Catalog No. T78970
"Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing the endonuclease functions of MRE11, thereby inducing apoptosis in CM cells [1]."
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
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Chemical Properties
| Description | "Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing the endonuclease functions of MRE11, thereby inducing apoptosis in CM cells [1]." |
| In vitro | Antitumor agent-96 (Compound D34; 72 h) exhibits selective cytotoxicity in CM cell lines CM-AS16 (IC50 = 2.9 ± 0.1 μM), CRMM2 (IC50 = 0.7 ± 0.0 μM), CM2005.1 (IC50 = 1.0 ± 0.1 μM), and CRMM1 (IC50 = 1.3 ± 0.3 μM) compared to ocular melanoma, cutaneous melanoma, and normal cells [1]. Additionally, Antitumor agent-96 (0.1-10 μM; 48 h) induces apoptosis in CRMM1 cells, inhibits CRMM1 cell migration, and increases DNA damage in CM cells while downregulating the HR pathway MRN complex [1]. |
| In vivo | Antitumor agent-96 dihydrochloride (Compound D34 dihydrochloride; 10 and 20 mg/kg; i.p.; administered five times per week for 28 days) exhibited antitumor activity in mice [1]. |
| Molecular Weight | 416.56 |
| Formula | C27H32N2O2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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