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Pack Size | Price | Availability | Quantity |
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5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | "Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing the endonuclease functions of MRE11, thereby inducing apoptosis in CM cells [1]." |
In vitro | Antitumor agent-96 (Compound D34; 72 h) exhibits selective cytotoxicity in CM cell lines CM-AS16 (IC 50 = 2.9 ± 0.1 μM), CRMM2 (IC 50 = 0.7 ± 0.0 μM), CM2005.1 (IC 50 = 1.0 ± 0.1 μM), and CRMM1 (IC 50 = 1.3 ± 0.3 μM) compared to ocular melanoma, cutaneous melanoma, and normal cells [1]. Furthermore, Antitumor agent-96 (0.1-10 μM; 48 h) induces apoptosis in CRMM1 cells [1], inhibits CRMM1 cell migration [1], and increases DNA damage accumulation in CM cells, while downregulating the HR pathway MRN complex [1]. |
In vivo | Antitumor agent-96 dihydrochloride (Compound D34 dihydrochloride; 10 and 20 mg/kg; i.p.; five times per week for 28 days) demonstrated antitumor activity in mice [1]. |
Molecular Weight | 416.56 |
Formula | C27H32N2O2 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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