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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $55 | In Stock | |
25 mg | $77 | In Stock | |
50 mg | $97 | In Stock | |
100 mg | $122 | In Stock | |
200 mg | $178 | In Stock | |
500 mg | $297 | In Stock | |
1 mL x 10 mM (in DMSO) | $43 | In Stock |
Description | Arachidonic acid (Immunocytophyte) is an unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. |
In vitro | METHODS: RAW264.7 and PBMC-derived macrophages were treated with Arachidonic acid (40-80 µM) for 12-24 h and cell viability was determined by CCK8 assay. RESULTS: Arachidonic acid significantly inhibited macrophage viability in a dose-dependent manner within 12 h, and more inhibition was observed between 12 h and 24 h. Arachidonic acid was also shown to inhibit macrophage viability in a dose-dependent manner. [1] METHODS: Human breast cancer cells, MDA-MB-231, were treated with Arachidonic acid (8 µM) for 48 h. Caspase activity was measured using a spectrofluorophotometer. RESULTS: MDA-MB-231 cells stimulated with Arachidonic acid for 48 h showed a significant increase in caspase-3 activity, and Arachidonic acid also induced significant activation of caspase-8 and caspase-9. [2] |
In vivo | METHODS: To test the effect on the inflammatory response, Arachidonic acid (150 mg/kg in 1% CMC Na) was administered orally to C57BL/6 mice with high-fat diet (HFD)-induced cardiac injury every two days for eight weeks. RESULTS: Arachidonic acid treatment prevented MD2/TLR4 dimerization, induction of inflammatory factors, and tissue damage through TLR4-mediated inflammatory responses in a high-fat diet obese mouse model. [3] |
Alias | Immunocytophyte, arachidonate, Immunocytophyt, Vevodar |
Molecular Weight | 304.47 |
Formula | C20H32O2 |
Cas No. | 506-32-1 |
Storage | keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | 5% DMSO+95% Saline: 0.6 mg/mL (1.97 mM, precipitation) DMSO: 100 mg/mL (328.4 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/5% DMSO+95% Saline
DMSO
|
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