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AS-35

Catalog No. T14326Cas No. 108427-72-1

AS-35 is an orally effective, potent, and selective antagonist of leukotrienes, antagonizing LTC4-, LTD4-, and LTE4-induced ileum contractions with IC50 values of 8 nM, 4 nM, and 3 nM, respectively. It exhibits antiallergic activities.

AS-35

AS-35

Purity: 98.68%
Catalog No. T14326Cas No. 108427-72-1
AS-35 is an orally effective, potent, and selective antagonist of leukotrienes, antagonizing LTC4-, LTD4-, and LTE4-induced ileum contractions with IC50 values of 8 nM, 4 nM, and 3 nM, respectively. It exhibits antiallergic activities.
Pack SizePriceAvailabilityQuantity
1 mg$293In Stock
2 mg$436In Stock
5 mg$722In Stock
10 mg$987In Stock
25 mg$1,520In Stock
50 mg$1,980In Stock
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Purity:98.68%
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Product Introduction

Bioactivity
Description
AS-35 is an orally effective, potent, and selective antagonist of leukotrienes, antagonizing LTC4-, LTD4-, and LTE4-induced ileum contractions with IC50 values of 8 nM, 4 nM, and 3 nM, respectively. It exhibits antiallergic activities.
Targets&IC50
LTD4:4 nM (isolated guinea pig ileum), LTC4:8 nM (isolated guinea pig ileum), LTE4:3 nM (isolated guinea pig ileum)
In vitro
In the trachea, the drug also antagonized LTD4- and LTE4-induced contraction with IC50 values ​​of 10 nM and 20 nM, respectively. In isolated guinea pig preparations, AS-35 antagonized LTC4, LTD4, and LTE4-induced ileal contractions with IC50 values ​​of 8 nM, 4 nM, and 3 nM, respectively. AS-35 does not antagonize LTC4-induced tracheal constriction in the presence of L-serine borate [1].
In vivo
AS-35 (p.o.) inhibits LTD4-induced increase in vascular permeability in guinea pig skin [1]. Oral administration of AS-35 also antagonized LTD4 as well as antigen-induced LT-mediated bronchoconstriction. AS-35 (0.0375 to 0.3 mg/kg, i.v.) dose-dependently antagonized bronchoconstriction induced by intravenous administration of LTC4 and LTD4 but not histamine-induced bronchoconstriction in anesthetized guinea pigs.[1]
Chemical Properties
Molecular Weight420.42
FormulaC21H20N6O4
Cas No.108427-72-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

AS 35AS35AS-35
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