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Bay 41-4109 (less active enantiomer)

Catalog No. T10480Cas No. 476617-51-3

Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).

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Pack Size	Price	Availability
5 mg	$293	Backorder
10 mg	$443	Backorder
50 mg	$1,323	Backorder
100 mg	$1,850	Backorder
200 mg	Inquiry	Backorder
500 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$256	Backorder

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Product Introduction

Bioactivity

Description

Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).

In vivo

BAY 41-4109 exhibits dose-dependent reductions in viral DNA levels in both the liver and plasma, demonstrating effectiveness commensurate with 3TC. It also diminishes the hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic analyses reveal swift absorption, a 30% bioavailability in mice, and dose-proportional plasma concentrations, reaching approximately 60% in rats and dogs [1]. Furthermore, BAY41-4109 disrupts in vivo virus production through a mechanism that interacts with the viral capsid [2].

Chemical Properties

Molecular Weight	395.76
Formula	C18H13ClF3N3O2
Cas No.	476617-51-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 37 mg/mL (93.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5268 mL	12.6339 mL	25.2678 mL	126.3392 mL
5 mM	0.5054 mL	2.5268 mL	5.0536 mL	25.2678 mL
10 mM	0.2527 mL	1.2634 mL	2.5268 mL	12.6339 mL
20 mM	0.1263 mL	0.6317 mL	1.2634 mL	6.3170 mL
50 mM	0.0505 mL	0.2527 mL	0.5054 mL	2.5268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc