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Bay 41-4109
Catalog No. T10480LCas No. 298708-81-3
BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
Bay 41-4109
Catalog No. T10480LCas No. 298708-81-3
BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $386 | 5 days | |
| 25 mg | $2,270 | 6-8 weeks | |
| 50 mg | $2,980 | 6-8 weeks | |
| 100 mg | $4,180 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. |
| Targets&IC50 | HBV:53 nM |
| In vitro | BAY 41-4109 effectively accelerates and alters the direction of capsid assembly in vitro, demonstrating potent inhibitory effects on both HBV DNA release and cytoplasmic HBcAg levels, with IC50 values of 32.6 and 132 nM in HepG2.2.15 cells, respectively. Its inhibitory action on HBV DNA and HBcAg is dose-dependent, underscoring that its anti-HBV properties hinge on the rate at which HBcAg is inhibited. Additionally, BAY 41-4109 can stabilize preformed capsids, achieving a stabilization ratio of one inhibitor molecule per two dimers. |
| In vivo | BAY 41-4109 effectively suppresses virus production in vivo through a mechanism focusing on the viral capsid[2]. It dose-dependently decreases viral DNA in both the liver and plasma, showing efficacy on par with 3TC, and it diminishes hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic evaluations in mice reveal quick absorption, 30% bioavailability, and dose-proportional plasma concentrations, reaching approximately 60% in rats and dogs[1]. |
| Molecular Weight | 395.76 |
| Formula | C18H13ClF3N3O2 |
| Cas No. | 298708-81-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (252.68 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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