Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Bazinaprine is a selective, reversible monoamine oxidase inhibitor (MAOI) that is a candidate compound for the treatment of depression. Bazinaprine showed strong inhibitory effect on type A monoamine oxidase and weak inhibitory effect on type b monoamine oxidase. Bazinaprine is reversible in vivo, but not in vitro.
Description | Bazinaprine is a selective, reversible monoamine oxidase inhibitor (MAOI) that is a candidate compound for the treatment of depression. Bazinaprine showed strong inhibitory effect on type A monoamine oxidase and weak inhibitory effect on type b monoamine oxidase. Bazinaprine is reversible in vivo, but not in vitro. |
Targets&IC50 | MAO-A:3-5mg/kg(ED50) |
In vitro | Bazinaprine(SR 95191) inhibits MAO-A in a time-dependent manner in vitro and appears to be irreversible.[1] The inhibition of brain MAO-A, but not MAO-B, by SR 95191 was time dependent, with a 19-fold decrease in the IC50 values being observed over a 30-min incubation period (140 to 7.5 μM).[2] |
In vivo | Bazinaprine (1–100 mg/kg, p.o.) antagonized, in a dose-dependent fashion, the irreversible inhibition of brain and liver MAO-A induced by phenelzine.[2] |
Molecular Weight | 309.37 |
Formula | C17H19N5O |
CAS No. | 94011-82-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 22.5 mg/mL (72.73 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Bazinaprine 94011-82-2 Metabolism Neuroscience MAO SR 95191 Inhibitor inhibitor inhibit