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Bazinaprine

Catalog No. T67789 CAS 94011-82-2

Bazinaprine is a selective, reversible monoamine oxidase inhibitor (MAOI) that is a candidate compound for the treatment of depression. Bazinaprine showed strong inhibitory effect on type A monoamine oxidase and weak inhibitory effect on type b monoamine oxidase. Bazinaprine is reversible in vivo, but not in vitro.

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Bazinaprine, CAS 94011-82-2

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Bazinaprine is a selective, reversible monoamine oxidase inhibitor (MAOI) that is a candidate compound for the treatment of depression. Bazinaprine showed strong inhibitory effect on type A monoamine oxidase and weak inhibitory effect on type b monoamine oxidase. Bazinaprine is reversible in vivo, but not in vitro.
Targets&IC50	MAO-A:3-5mg/kg(ED50)
In vitro	Bazinaprine(SR 95191) inhibits MAO-A in a time-dependent manner in vitro and appears to be irreversible.[1] The inhibition of brain MAO-A, but not MAO-B, by SR 95191 was time dependent, with a 19-fold decrease in the IC50 values being observed over a 30-min incubation period (140 to 7.5 μM).[2]
In vivo	Bazinaprine (1–100 mg/kg, p.o.) antagonized, in a dose-dependent fashion, the irreversible inhibition of brain and liver MAO-A induced by phenelzine.[2]

Molecular Weight	309.37
Formula	C17H19N5O
CAS No.	94011-82-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 22.5 mg/mL (72.73 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Luque J M, et al. Radioautographic Evidence that the GABAA Receptor Antagonist SR 95531 is a Substrate Inhibitor of MAO‐A in the Rat and Human Locus Coeruleus. European Journal of Neuroscience, 1994;6(6): 1038-1049. 2. Kan JP, et al. Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: evidence for selective and reversible inhibition of monoamine oxidase type A in vivo but not in vitro. J Neurochem. 1988;50(4):1137-1144.

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Keywords

Bazinaprine 94011-82-2 Metabolism Neuroscience MAO SR 95191 Inhibitor inhibitor inhibit

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